Buy Ticlid Online | Ticlid (Ticlopidine) Prescription Medication
Ticlid (Ticlopidine) Information
Ticlid, with the active ingredient Ticlopidine, is an antiplatelet medication used to prevent blood clots. It is available in tablet form for oral administration.
Composition
Active Ingredient: Ticlopidine hydrochloride.
Forms of Release: Ticlid is typIcally supplied as film-coated tablets, each containing 250 mg of Ticlopidine hydrochloride.
Indications
Ticlopidine is primarily indicated for the reduction of the risk of thrombotic events in patients who:
- Have had a recent myocardial infarction.
- Have had a recent stroke or transient ischemic attack (TIA).
- Have peripheral arterial disease, including intermittent claudication.
- Are undergoing coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) and are at high risk for embolic complications.
- Have certain types of vascular access grafts where thrombosis is a concern.
Mechanism of Action
Ticlopidine is a thienopyridine derivative that acts as an irreversible inhibitor of the adenosine diphosphate (ADP) P2Y12 receptor on the surface of platelets. By blocking this receptod, Ticlopidine prevents ADP-mediated platelet activation and aggregation. This effect reduces the formation of platelet-rich thrombi, which are implicated in the pathogenesis of arterial thrombosis. The onset of action is typically within 2 hours, with maximal inhibition of platelet aggregation achieved within 3-5 days of continuous therapy. The effect is irreversible for the lifespan of the platelet (7-10 days).
Safety Profile
Benefits: Ticlopidine has demonstrated efficacy in reducing the incidence of ischemic events in high-risk populations.
Potential Side Effects: Common side effects include diarrhea, nausea, dyspepsia, rash, pruritus, and neutropenia. More serious adverse events can include severe neutropenia, agranulocytosis, thrombotic thrombocytopenic purpura (TTP), severe diarrhea, and gastrointestinal bleeding. Hematologic monitoring is crucial during treatment.
Contraindications: Ticlopidiine is contraindicated in patients with a known hypersensitivity to the drug, active bleeding, a history of neutropenia or thrombocytopenia, or severe liver disease.
Warnings: Patients should be monitored closely for signs of bleeding, infection, or hematologic abnormalities. Use with caution in patients with hepatic or renal impairment. Discontinuation may be necessary if severe diarrhea or hematologic issues arise.
Dosage Table
| Disease/Condition | Recommended Dosage | Treatment Duration |
|---|---|---|
| Recent Myocardial Infarction | 250 mg twice daily | Generally 1 month, or longer as advised |
| Recent Stroke/TIA | 250 mg twice daily | Generally 1 year, or longer as advised |
| Peripheral Arterial Disease | 250 mg twice daily | Indefinite, depending on clinical response |
| Post-PTCA/CABG | 250 mg twice daily | Usually 1 month, or as determined by cardiologist |
Frequently Asked Questions
Q1: How long does Ticlid take to start working?
A1: Ticlopidine's antiplatelet effect typically begins within 2 hours of the first dose, with significant inhibition of platelet aggregation occurring within 3-5 days of consistent daily dosing.
Q2: What are the most serious side effects of Ticlopidine?
A2: The most serious potential side effects include severe neutropenia (low white blood cell count), agranulocytosis, thrombotic thrombocytopenic purpura (TTP), and severe gastrointestinal bleeding. Regular blood monitoring is essential.
Q3: Can Ticlid be taken with other medications?
A3: Ticlopidine can interact with other medications, particularly those affecting blood clotting or gastric pH. It is crucial to inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements.
Q4: What should I do if I miss a dose of Ticlid?
A4: If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.