Buy Lopinavir 200mg/Ritonavir 50mg Online - Best Prices & Deals
Lopinavir 200mg/Ritonavir 50mg: Comprehensive Information
Lopinavir 200mg/Ritonavir 50mg is a combination antiretroviral medication used in the management of Human Immunodeficiency Virus (HIV) infection. It is typically available in capsule or oral solution forms.
Composition:
- Active Ingredients: Lopinavir and Ritonavir.
- Formulations: Capsules (200mg Lopinavir / 50mg Ritonavir) and Oral Solution (80mg Lopinavir / 20mg Ritonavir per mL).
Indications:
This medication is indicated for the treatment of HIV-1 infection in combination with other antiretroviral agents in adult and pediatric patients (as young as 2 weeks of age). It is part of a comprehensive HIV treatment regimen.
Mechanism of Action:
Lopinavir is a protease inhibitor that works by blocking the activity of HIV protease, an enzyme that HIV needs to replicate. By inhibiting this enzyme, lopinavir prevents the maturation of new virus particles, thereby reducing the viral load in the body. Ritonavir, also a protease inhibitor, is used in a lower dose in thIs combination. Its primary role is to boost the levels of lopinavir in the bloodstream by inhibiting the cytochrome P450 3A4 (CYP3A4) enzyme system, which metabolizes lopinavir. This pharmacokinetic boosting allows for less frequent dosing and improved efficacy of lopinavir.
Safety Profile:
- Benefits: Effective in reducing viral load, increasing CD4 cell counts, and slowing the progression of HIV disease.
- Common Side Effects: Gastrointestinal disturbances (diarrhea, nausea, vomiting), headache, fatigue, and hypertriglyceridemia.
- Serious Side Effects: Liver problems (hepatitis), pancreatitis, diabetes mellitus, fat redistribution (lipodystrophy), and hypersensitivity reactions.
- Contraindications: Hypersensitivity to lopinavir or ritonavir. Concurrent use with certain medications that are metabolized by CYP3A4 (e.g., rifampin, certain statins, St. John's Wort) may be contraindicated due to potential drug interactions.
- Warnings: Patients with pre-existing liver disease, diabetes, or pancreatitis should be closely monitored. Caution is advised in patients with a history of cardiac arrhythmias, as ritonavir can prolong the QT interval.
Dosage Table:
| Condition | Dosage Form | Recommended Dosage | Treatment Duration |
|---|---|---|---|
| HIV-1 Infection (Adults) | Capsules | 400mg Lopinavir / 100mg Ritonavir (two 200mg/50mg capsules) twice daily | As prescribed by a healthcare professional, typically lifelong |
| HIV-1 Infection (Pediatrics, 6 months to 13 years or < 42 kg) | Oral Solution | 230mg Lopinavir / 57.5mg Ritonavir per m2 of body surface area twice daily | As prescribed by a healthcare professional |
| HIV-1 Infection (Pediatrics, 2 weeks to 6 months) | Oral Solution | 12mg Lopinavir / 3mg Ritonavir per kg of body weight ttwice daily | As prescribed by a healthcare professional |
Note: Dosages may need adjustment based on co-administered medications and individual patient factors. Always consult a healthcare provider for personalized dosage instructions.
Frequently Asked Questions:
1. How should Lopinavir/Ritonavir be stored?
Capsules should be stored at room temperature (20°C to 25°C or 68°F to 77°F), protected from light and moisture. Oral solutions may require refrigeration depending on the specific product formulation; always check the manufacturer's instructions. Keep out of reach of children.
2. Can I take Lopinavir/Ritonavir with food?
Yes, Lopinavir/Ritonavir can be taken with or without food. However, taking it with food may help reduce gastrointestinal side effects like nausea. For the oral solution, it is recommended to mix it with a small amount of water, milk, or formula.
3. What are the most common drug interactions?
Lopinavir/Ritonavir can interact with many medications due to ritonavir's potent inhibition of CYP3A4. Significant interactions can occur with certain anticonvulsants (e.g., carbamazepine, phenytoin), antiarrhythmics (e.g., amiodarone), antifungals (e.g., ketoconazole), erectile dysfunction agents, and herbal products like St. John's Wort. Always inform your doctor and pharmacist about all medications, supplements, and herbal products you are taking.
4. Is Lopinavir/Ritonavir a cure for HIV?
No, Lopinavir/Ritonavir is not a cure for HIV infection. It is an antiretroviral therapy that helps to control the virus, allowing individuals with HIV to live longer, healthier lives. Antiretroviral therapy reduces the risk of HIV transmission to others. Continued treatment and adherence are crucial.
5. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it is close to the time for your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Contact your healthcare provider or pharmacist if you are unsure about what to do.
