Buy Arcoxia Online | Etoricoxib Pain Relief Deals
Arcoxia (Etoricoxib) Information
Arcoxia is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme. This selective inhibition reduces the production of prostaglandins, which are key mediators of inflammation, pain, and fever. Unlike traditional NSAIDs, Arcoxia has a lower risk of gastrointestinal side effects because it does not significantly inhibit the COX-1 enzyme, which plays a role in protecting the stomach lining.
Composition and Forms
The active ingredient in Arcoxia is etoricoxib. It is available in tablet form, typically in strengths of 30 mg, 60 mg, 90 mg, and 120 mg.
Indications
Arcoxia is prescribed for the symptomatic treatment of:
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
- Ankylosing spondylitis (AS)
- Chronic low back pain
- Acute gouty arthritis
- Symptomatic relief of pain and inflammation in acute musculoskeletal disorders
- Symptomatic relief of acute pain
- Primary dysmenorrhea
Mechanism of Action
Etoricoxib works by selectively blocking the COX-2 enzyme. COX-2 is an inducible enzyme that is produced in response to inflammatory stimuli. By inhibiting COX-2, etoricoxib reduces the synthesis of prostaglandins, leading to:
- Reduced inflammation
- Pain relief (analgesia)
- Reduced fever (antipyresis)
Its selectivity for COX-2 over COX-1 is thought to contribute to its improved gastrointestinal safety profile compared to non-selective NSAIDs.
Safety Profile
Benefits: Effective pain and inflammation relief with potentially reduced gastrointestinal risks.
Potential Side Effects: Common sude effects include swelling (edema), dizziness, headache, palpitations, shortness of breath, abdominal pain, diarrhea, indigestion, nausea, vomiting, and rash. Less common but serious side effects can include cardiovascular events (heart attack, stroke), gastrointestinal bleeding, kidney problems, and allergic reactions.
Contraindications: Arcoxia should not be used in patients with:
- Hypersensitivity to etoricoxib or any of its excipients
- Active peptic ulceration or active inflammatory gastrointestinal disease
- Severe hepatic impairment (Child-Pugh score >9)
- Renal impairment (serum creatinine >3.0 mg/dL or equivalent)
- Inflammatory bowel disease
- Congestive heart failure (NYHA II-IV)
- Established ischemic heart disease, peripheral arterial disease, or cerebrovascular disease
- Hypertension that is not adequately cintrolled
- Pregnancy and breastfeeding
Warnings: Caution is advised in patients with risk factors for cardiovascular disease, those with pre-existing heart conditions, hypertension, or those taking anticoagulants. Patients with dehydration, hepatic impairment, or renal impairment should use with caution and under medical supervision.
Dosage Table
| Condition | Recommended Dosage | Treatment Duration |
|---|---|---|
| Osteoarthritis | 60 mg once daily | As needed for symptom relief, typically ongoing |
| Rheumatoid Arthritis | 90 mg once daily | As needed for symptom relief, typically ongoing |
| Ankylosing Spondylitis | 90 mg once daily | As needed for symptom relief, typically ongoing |
| Chronic Low Back Pain | 60 mg or 90 mg once daily | Up to 12 weeks |
| Acute Gouty Arthritis | 120 mg once daily | Maximum 8 days |
| Acute Pain | 90 mg once daily | Maximum 7 days |
| Primary Dysmenorrhea | 120 mg once daily | Maximum 3 days |
Note: Dosages should be individualized based on patient response and tolerability. The lowest effective dose should be used for the shortest duration necessary.
Frequently Asked Questions
What is the main active ingredient in Arcoxia?
The main active ingredient in Arcoxia is etoricoxib, which belongs to a class of drugs called selective COX-2 inhibitors.
Can Arcoxia be taken with food?
Yes, Arcoxia can be taken with or without food. However, taking it with food may help reduce the risk of stomach upset for some individuals.
How long does it take for Arcoxia to start working?
The onset of pain relief can vary. Some patients may feel relief within a few hours, while for others, it may take a day or two to notice significant improvement in symptoms.
Is Arcoxia safe for long-term use?
Arcoxia is intended for short-term symptomatic relief. While it can be used for chronic conditions like arthritis, long-term use should be carefully monitored by a healthcare professional due to potential risks, particularly cardiovascular and gastrointestinal effects.
