Buy Calcitriol Capsules Online | Prescription Required
Calcitriol: Comprehensive Information
Calcitriol is the hormonally active form of vitamin D. It is a synthetic analog of vitamin D that is used to treat various medical conditions related to calcium and phosphate metabolism. It is available in several forms, including capsules, oral solution, and intravenous injection.
Composition and Forms
Active Ingredient: Calcitriol
Forms of Release:
- Capsules (e.g., 0.25 mcg, 0.5 mcg, 1 mcg)
- Oral Solution (e.g., 1 mcg/mL)
- Intravenous Solution (for injection)
Indications
Calcitriol is prescribed for the following conditions:
- Secondary Hyperparathyroidism: Commonly seen in patients with chronic kidney disease (CKD).
- Hypocalcemia: Low calcium levels in patients with hypoparathyroidism (surgical or idiopathic), pseudohypoparathyroidism, and renal osteodystrophy.
- Osteoporosis: To help manage bone density.
- Psoriasis: Topical formulations may be used.
- Rickets and Osteomalacia: Vitamin D-resistant rickets and osteomalacia.
Mechanism of Action
Calcitriol is the active metabolite of vitamin D. It functions as a hormone that regulates calcium and phosphate homeostasis. It increases intestinal absorption of calcium and phosphate, reduces calcium excretion by the kidneys, and promotes bone mineralization. In patients with CKD, it helps suppress the overproduction of parathyroid hormone (PTH) by the parathyroid glands, thereby alleviating secondary hyperparathyroidism.
Safety Profile
POtential Benefits: Effective in managing calcium and phosphate imbalances, reducing PTH levels in CKD patients, and improving bone health.
Common Side Effects: Hypercalcemia (high calcium levels) is the most significant risk. Symptoms include nausea, vomiting, constipation, loss of appetite, increased thirst, frequent urination, and weakness. Other side effects can include headache, dry mouth, and metallic taste.
Contraindications: Calcitriol is contraindicated in patients with hypercalcemia or any sign of vitamin D toxicity. Caution should be exercised in patients with sarcoidosis or other granulomatous diseases due to increased sensitivity to vitamin D.
Warnings: Regular monitoring of serum calcium, phosphate, alkaline phosphatase, and PTH levels is crucial during treatment. Patients should be advised to avoid excessive intake of calcium and vitamin D from other sources.
Dosage Table
| Condition | Recommended Dosage | Treatment Duration |
|---|---|---|
| Secondary Hyperparathyroidism (CKD) | 0.25 mcg to 1 mcg daily (may be adjusted based on PTH levels) | Continuous |
| Hypoparathyroidism | 0.25 mcg to 1 mcg daily (titrated to maintain serum calcium) | Continuous |
| Renal Osteodystrophy | 0.25 mcg to 1 mcg daily (titrated to maintain serum calcium and phosphate) | Continuous |
| Vitamin D-Resistant Rickets/Osteomalacia | 1 mcg to 4 mcg daily (titrated to normalize serum phosphate) | Until biochemical parameters normalize, then maintenance dose |
Frequently Asked Questions
- What is the difference between Calcitriol and Vitamin D?
- Calcitriol is the active, hormonal form of vitamin D. While vitamin D needs to be converted in the liver and kidneys to become active, calcitriol is already in its active state and can directly exert its effects on calcium and phosphate metabolism.
- How should Calcitriol be stored?
- Calcitriol capsules and solutions should be stored at room temperature (20°C to 25°C or 68°F to 77°F), protected from light and moisture. Keep out of reach of children.
- Can I take Calcitriol with food?
- Calcitriol capsules are generally taken with meals to enhance absorption and minimize potential gastrointestinal upset. However, follow your healthcare provider's specific instructions.
- What are the signs of hypercalcemia?
- Signs of hypercalcemia include increased thirst, frequent urination, nausea, vomiting, constipation, stomach pain, fatigue, muscle weakness, confusion, and irregular heartbeat. Seek medical attention immediately if you experience these symptoms.